Growth of Small Numbers of Tubercle Bacilli, H37, in Long's Liquid Synthetic Medium and Some Interfering Factors.

Chemical Factors Influencing the Growth of Tubercle Bacilli: I. Metal Catalysts.

This investigation deals with the effects of cupric, manganous, ferric, and antimonate ions; extracts of calves' lungs, calves' hearts, and chicken livers; and of diphenylamine and other organic compounds; on the growth of H37, a human strain of tubercle bacilli. It was carried out at the suggestion of Dr. Kharasch, who, with his co-workers (Kharasch, Conway and Bloom, 1936), had studied the ef...

The Growth of Human Tubercle Bacilli, H37, in Synthetic Medium with and without Agar.

Serum Albumin as a Food for Human Tubercle Bacilli.

Before the development of egg mediums, serum was used extensively as a medium in the cultivation of tubercle bacilli. Eastwood in 1907 reported that horse, bovine, dog, and pig serums supported good growth of stock cultures of human and bovine tubercle bacilli and also served well as isolation mediums. Since the introduction of egg mediums there has been little use of serum as a medium in itsel...

A Method for the Determination of the Rate of Growth of Tubercle Bacilli by the Use of Small Inocula.

Older observations on the nutritive requirements and metabolism of virulent tubercle bacilli do not have quantitative significance because of the lack of accurate methods for the estimation of the rate of growth. The recognition in recent years that these organism grow just as well when submerged in liquid media as on the surface of liquid or solid media has eliminated some of the difficulties ...

The Tuberculostatic Effect of Subtilin in Vitro and in Vivo.

The antituberculosis activity of subtilin, an antibiotic agent introduced by Jansen and Hirschmann (1944), has been the subject of conflicting reports in the literature. Salle and Jann (1945) reported that subtilin in a dilution of 1:50,000 prevented surface growth of Mycobacterium tuberculosis on Long's synthetic medium, and that transfers into fresh medium made from tubes containing 1:10,000 ...